In this paper we discuss the scientific value of the human genome project. To what extent is the data obtained by sequencing the entire human genome useful in the gene dicovery process? Responding to Alex Rosenberg' skepticism about the value of such data, we maintain that brute sequence data is much more useful than he suggests.

Humans' voice offers the widest variety of motor phenomena of any human activity. However, its clinical evaluation in people with movement disorders such as Parkinson's disease lags behind current knowledge on advanced analytical automatic speech processing methodology. Here, we use deep learning-based speech processing to differentially analyze voice recordings in 14 people with PD before and after dopaminergic medication using personalized Convolutional Recurrent Neural Networks and Phone Attribute Codebooks. p-CRNN yields an accuracy of 82.35% in the binary classification of ON (...) and OFF motor states at a sensitivity/specificity of 0.86/0.78. The PAC-based approach's accuracy was slightly lower with 73.08% at a sensitivity/specificity of 0.69/0.77, but this method offers easier interpretation and understanding of the computational biomarkers. Both p-CRNN and PAC provide a differentiated view and novel insights into the distinctive components of the speech of persons with PD. Both methods detect voice qualities that are amenable to dopaminergic treatment, including active phonetic and prosodic features. Our findings may pave the way for quantitative measurements of speech in persons with PD. (shrink)

It was, until recently, accepted that the two classes of acetylcholine (ACh) receptors are distinct in an important sense: muscarinic ACh receptors signal via heterotrimeric GTP binding proteins (G proteins), whereas nicotinic ACh receptors (nAChRs) open to allow flux of Na+, Ca2+, and K+ ions into the cell after activation. Here we present evidence of direct coupling between G proteins and nAChRs in neurons. Based on proteomic, biophysical, and functional evidence, we hypothesize that binding to G proteins modulates the activity (...) and signaling of nAChRs in cells. It is important to note that while this hypothesis is new for the nAChR, it is consistent with known interactions between G proteins and structurally related ligand‐gated ion channels. Therefore, it underscores an evolutionarily conserved metabotropic mechanism of G protein signaling via nAChR channels.Also watch the Video Abstract. (shrink)

According to [M.S. Kurilić, Cohen-stable families of subsets of the integers, J. Symbolic Logic 66 257–270], adding a Cohen real destroys a splitting family on ω if and only if is isomorphic to a splitting family on the set of rationals, , whose elements have nowhere dense boundaries. Consequently, implies the Cohen-indestructibility of . Using the methods developed in [J. Brendle, S. Yatabe, Forcing indestructibility of MAD families, Ann. Pure Appl. Logic 132 271–312] the stability of splitting families in several (...) forcing extensions is characterized in a similar way . Also, it is proved that a splitting family is preserved by the Sacks forcing if and only if it is preserved by some forcing which adds a new real. The corresponding hierarchy of splitting families is investigated. (shrink)

Atque illo die certe Aricia rediens devertit Clodius ad se in Albanum: quod ut sciret Milo ilium Ariciae fuisse, suspicari tamen debuit eum, etiam si Romam illo die reverti vellet, ad villam suam, quae viam tangeret, deversurum. THIS passage is interesting in that its argument runs counter to the main picture which Cicero had earlier presented of the movements of Milo and Clodius before they met on the Appian Way in January 52 B.C. In an earlier passage Cicero (...) says: ‘Interim cum sciret Clodius–neque enim difficile erat id scire–xiter sollemne, legitimum, necessarium ante diem XIII Kalendas Februarias Miloni esse Lanuvium ad flaminem prodendum, quod erat dictator Lanuvii Milo, Roma subito ipse profectus pridie est, ut ante suum fundum, quod re intellectum est, Miloni insidias conlocaret.’ Cicero remains true to this latter version in all the relevant arguments concerning the motives and movements of Clodius and Milo. Milo had legitimate business at Lanuvium, and hence a legitimate reason for being on the road at the time of the affray; Clodius′ presence is explained by Cicero as due solely to the desire to place an ambush for his enemy at a convenient spot, i.e. in front of his farm, and for this reason he had set out from Rome a day before Milo, when his presence was really required in Rome. (shrink)

Atque illo die certe Aricia rediens devertit Clodius ad se in Albanum: quod ut sciret Milo ilium Ariciae fuisse, suspicari tamen debuit eum, etiam si Romam illo die reverti vellet, ad villam suam, quae viam tangeret, deversurum.THIS passage is interesting in that its argument runs counter to the main picture which Cicero had earlier presented of the movements of Milo and Clodius before they met on the Appian Way in January 52 B.C. In an earlier passage Cicero says: (...) ‘Interim cum sciret Clodius–neque enim difficile erat id scire–xiter sollemne, legitimum, necessarium ante diem XIII Kalendas Februarias Miloni esse Lanuvium ad flaminem prodendum, quod erat dictator Lanuvii Milo, Roma subito ipse profectus pridie est, ut ante suum fundum, quod re intellectum est, Miloni insidias conlocaret.’ Cicero remains true to this latter version in all the relevant arguments concerning the motives and movements of Clodius and Milo. Milo had legitimate business at Lanuvium, and hence a legitimate reason for being on the road at the time of the affray; Clodius′ presence is explained by Cicero as due solely to the desire to place an ambush for his enemy at a convenient spot, i.e. in front of his farm, and for this reason he had set out from Rome a day before Milo, when his presence was really required in Rome. (shrink)

Algorithms wield increasing control over our lives—over which jobs we get, whether we're granted loans, what information we're exposed to online, and so on. Algorithms can, and often do, wield their power in a biased way, and much work has been devoted to algorithmic bias. In contrast, algorithmic neutrality has gone largely neglected. I investigate three questions about algorithmic neutrality: What is it? Is it possible? And when we have it in mind, what can we learn about algorithmic bias?

Cieľom tohto článku nie je, primárne, rozobrať Popperovu teóriu vedy, ale 1. predstaviť Lakatosove námietky proti tejto teórii; 2. kriticky ich analyzovať z hľadiska Popperovej teórie; a 3. vysvetliť, prečo justifikacionista Lakatos nemohol oceniť Popperov skepticizmus.

The concept of cuteness, which can evoke positive emotions in people, is an essential aspect to consider in artificial intelligence design. This study aimed to investigate whether the use of baby schema designed avatars in computer-mediated communication elicits higher positive attitudes than neutral avatars and whether the ethnicity of the cute avatars influences individuals' perceived level of cuteness. 485 participants from Israel and Japan viewed six avatar images, including three baby schema avatars of different visual characteristics and ethnicities (Caucasian, Asian, (...) and Black) and three neutral avatars. Participants rated their attitudes on each avatar, and the results revealed that the baby schema designed avatars were rated cuter, more likable, approachable, and pleasant than the neutral mature avatars. Cultural differences were also evident, as the Caucasian baby schema avatar was rated cuter among Japanese participants, while the Asian and Black baby schema avatars were rated cuter among Israeli respondents. The study findings suggest that cute avatar design can serve as a powerful tool for promoting positive interactions in computer-mediated communication, especially in cultures that highly value cuteness, such as Japan. However, the subjective nature of cuteness is evident as attitudes toward cuteness varied significantly across cultures and individuals. This research highlights the significance of cultural diversity and emphasizes the importance of considering cuteness as a crucial aspect of artificial intelligence design, particularly when creating avatars intended to elicit positive emotions from users. Therefore, designers should be mindful of potential cultural and individual differences in the perception of cuteness while developing avatars for various applications. (shrink)

Very often moral disagreements can be resolved by appealing to factual considerations because in these cases the parties to the dispute agree as to which factual considerations are relevant. They agree, that is, with respect to their basic moral standards. Hence, when their disagreement about the non-moral facts is resolved, so is their moral disagreement. But sometimes moral disagreement persists in spite of agreement on factual considerations. When this happens, and when neither party is guilty of illogical thinking, we have (...) a case of moral deadlock. (shrink)

The article provides a critical review of the books Rijec je o slici by Jagor Bucan and Slika i rec by the Serbian Society for Aesthetics. From the titles it is already evident that they share the same topic. The paper points out the similarities between the two texts on both what is present and what is absent in them, which also seems important for understanding the theoretical problems they deal with.

The book presents Transparent Intensional Logic in several of its latest realisations in such a way that it makes a case for the system and demonstrates how the theory can be applied to a wide range of cases.

At the basis of tireless efforts to explain the nature of law lies the question of how judges should decide cases. Therefrom arises a need for a theory that would clarify the role of the courts and, moreover, provide guidance to them on reaching judgments. The history of legal theory abounds with various attempts to offer a generally acceptable answer to the question raised. The fervor of debate and the perpetual dissatisfaction with offered solutions prompted the thought of untamable arbitrariness (...) of judges. In the contemporary debate the significance of argumentation is particularly emphasized as a link of the court procedure which provides reasonableness and therewith justification and persuasiveness of the decision. Before going into the matter, I will indicate in broad strokes which areas of legal theory do argumentation and interpretation belong to. The purpose of setting a conceptual framework is to prevent losing sight of the whole as well as to limit the scope of discourse to a certain section of legal issues. The second part deals with the concept of argumentation in general and some specific features of the argumentation in law. The third part examines the role of legal interpretation and draws a clear distinction between the interpretation as a process and the interpretation as a result. At the end of the discussion I shall put forward a thesis that the interpretation as a process is argumentation, while the interpretation as a result is an argument in the justification of judgment. nema. (shrink)

To model behavioral and neural correlates of language comprehension in naturalistic environments, researchers have turned to broad‐coverage tools from natural‐language processing and machine learning. Where syntactic structure is explicitly modeled, prior work has relied predominantly on context‐free grammars (CFGs), yet such formalisms are not sufficiently expressive for human languages. Combinatory categorial grammars (CCGs) are sufficiently expressive directly compositional models of grammar with flexible constituency that affords incremental interpretation. In this work, we evaluate whether a more expressive CCG provides a better (...) model than a CFG for human neural signals collected with functional magnetic resonance imaging (fMRI) while participants listen to an audiobook story. We further test between variants of CCG that differ in how they handle optional adjuncts. These evaluations are carried out against a baseline that includes estimates of next‐word predictability from a transformer neural network language model. Such a comparison reveals unique contributions of CCG structure‐building predominantly in the left posterior temporal lobe: CCG‐derived measures offer a superior fit to neural signals compared to those derived from a CFG. These effects are spatially distinct from bilateral superior temporal effects that are unique to predictability. Neural effects for structure‐building are thus separable from predictability during naturalistic listening, and those effects are best characterized by a grammar whose expressive power is motivated on independent linguistic grounds. (shrink)

First published in 1982, this reissue contains a critical exposition of the views of Frege, Dedekind and Peano on the foundations of arithmetic. The last quarter of the 19th century witnessed a remarkable growth of interest in the foundations of arithmetic. This work analyses both the reasons for this growth of interest within both mathematics and philosophy and the ways in which this study of the foundations of arithmetic led to new insights in philosophy and striking advances in logic. This (...) historical-critical study provides an excellent introduction to the problems of the philosophy of mathematics - problems which have wide implications for philosophy as a whole. This reissue will appeal to students of both mathematics and philosophy who wish to improve their knowledge of logic. (shrink)

By and large, contemporary news stories are stories about a particular nation, told to an audience that is seen and addressed in national terms. However, the understanding of the exact ways in which national imagination becomes engrained in the narrative conventions of news reporting is still rather limited, in particular when it comes to audiovisual genres. This article aims to fill a part of this blank by examining the links between national imagination and the narrative conventions of television news. Building (...) on existing debates about different modes of news reporting, the article distinguishes two distinct sets of narrative conventions at work in television news: one typically found in routine reporting, the other characteristic of crisis and celebratory reporting. It is argued that each of these two sets of conventions is tied to a different form of nationalism, and normally arises in a different political climate. Links between national imagination and narrative conventions vary accordingly. To demonstrate this, the article provides a comparative analysis of narrative structures in selected samples of television news bulletins broadcast in the early 1990s in the Socialist Federal Republic of Yugoslavia. The concluding section reflects on the external validity of the chosen case study and surveys supportive evidence from four other relevant cases, drawn from the UK and Israel. (shrink)

You want to see the concert, but don’t want to take a long drive (even though the concert is far away). Such *strongly conflicting desire ascriptions* are, I show, wrongly predicted incompatible by standard semantics. I then object to possible solutions, and give my own, based on *some-things-considered desire*. Considering the fun of the concert, but ignoring the drive, you want to see the concert; considering the boredom of the drive, but ignoring the concert, you don’t want to take the (...) drive. (shrink)

This is a companion to a paper by the authors entitled “Gödel’s natural deduction,” which presented and made comments about the natural deduction system in Gödel’s unpublished notes for the elementary logic course he gave at the University of Notre Dame in 1939. In that earlier paper, which was itself a companion to a paper that examined the links between some philosophical views ascribed to Gödel and general proof theory, one can find a brief summary of Gödel’s notes for the (...) Notre Dame course. In order to put the earlier paper in proper perspective, a more complete summary of these interesting notes, with comments concerning them, is given here. (shrink)